Workshop on Modeling Reactive Toxicity, Logan, UT, March 23-24, 2010
|
3rd Workshop on Reactive Toxicity University Inn and Conference Center Utah State University March 23-24, 2010Predicting the hazards of reactive chemicals is a major uncertainty in safety assessment because of inadequate models for chemical reactivity, itself. Two IQF retreats in Knoxville explored the role of reactive toxicity in predictive toxicology and published a conceptual framework for improving QSAR models for chemical reactivity. That framework outlined a series of systematic databases for model compounds which mimic reactive sites in biological systems. T.W Schultz et al. created the first of the databases for glutathione reactivity, and the data are used to predict a variety of assessment endpoints such as skin and lung sensitization, aquatic toxicity and cellular assays. The Logan retreat by invitation only will review progress and discuss options for the next database. |
Workshop Goals Saturday, 13 February 2010 08:02 |  |  | 
The International QSAR Foundation has invited a number of international experts from the European Union, Canada, and the USA to a retreat at Utah State University in Logan, Utah to evaluate the use of model nucleophiles as an organizing principle for predicting the many adverse effects of reactive chemicals. Predicting the effects of chemicals involves the prediction of molecular interactions with biological systems as well as the biological consequences of those interactions. Reactive chemicals form covalent bonds with macromolecules which increases the potency of chemicals as well as the spectrum of long-term effects. Chemicals that selectively bind to thiol groups in proteins commonly impact the immune system which is observed as skin and lung sensitization as well as delayed organ failure. Our framework suggests that if the reaction rates of chemicals toward model nucleophiles such as glutathione and lysine can be predicted, the reaction rates will correlate with endpoints used to assess skin sensitization, inhalation toxicity, hepatocyte toxicity and aquatic toxicity. Last Updated (Saturday, 13 February 2010 08:05) |
|
|
Donate
Download
Jun. 18,2012 - Jun. 22,2012
The 15th International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR2012)., Sokos Hotel Viru, Tallinn, Estonia
